IL13RA2 Protein (AA 27-343) (FITC,His tag)
Quick Overview for IL13RA2 Protein (AA 27-343) (FITC,His tag) (ABIN6950960)
Target
See all IL13RA2 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 27-343
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Purification tag / Conjugate
- This IL13RA2 protein is labelled with FITC,His tag.
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Interleukin 13 Receptor, alpha 2 (IL13RA2) (AA 27-342) protein (Fc Tag)
IL13RA2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 13 Receptor, alpha 2 (IL13RA2) (AA 27-343) (Active) protein (Fc Tag)IL13RA2 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 13 Receptor, alpha 2 (IL13RA2) (AA 27-340) protein (Fc Tag)IL13RA2 Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 13 Receptor, alpha 2 (IL13RA2) (AA 27-126) protein (GST tag)IL13RA2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 13 Receptor, alpha 2 (IL13RA2) (AA 27-343) (Active) protein (His tag)IL13RA2 Origin: Human Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. SDS, WB, Imm, ELISA, AcA Active
Interleukin 13 Receptor, alpha 2 (IL13RA2) (AA 27-343) protein (His tag)IL13RA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % SDS
Interleukin 13 Receptor, alpha 2 (IL13RA2) (AA 27-343) protein (hIgG-His-tag)IL13RA2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 85 % SDS
Interleukin 13 Receptor, alpha 2 (IL13RA2) (Active) protein (His tag,Fc Tag)IL13RA2 Origin: Mouse Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Interleukin 13 Receptor, alpha 2 (IL13RA2) (Active) protein (His tag)IL13RA2 Origin: Rat Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Interleukin 13 Receptor, alpha 2 (IL13RA2) (Active) protein (Fc Tag)IL13RA2 Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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- IL13RA2 (Interleukin 13 Receptor, alpha 2 (IL13RA2))
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Alternative Name
- IL-13 R alpha 2
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Background
- Interleukin-13 receptor subunit alpha-2 is also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain. In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-beta production and fibrosis. Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.
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Molecular Weight
- 39.0 kDa
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NCBI Accession
- NP_000631
Target
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