EPH Receptor A4 Protein (EPHA4) (AA 20-547) (His tag)
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- Target See all EPH Receptor A4 (EPHA4) Proteins
- EPH Receptor A4 (EPHA4)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 20-547
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This EPH Receptor A4 protein is labelled with His tag.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product EPHA4 Protein
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EPH Receptor A4 (EPHA4) (AA 20-547) protein (His tag)
EPHA4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A4 (EPHA4) (AA 20-547) protein (His tag)EPHA4 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A4 (EPHA4) (AA 887-986) protein (GST tag)EPHA4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
EPH Receptor A4 (EPHA4) (AA 1-105) protein (GST tag)EPHA4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
EPH Receptor A4 (EPHA4) (AA 1-986) protein (GST tag)EPHA4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
EPH Receptor A4 (EPHA4) (AA 570-986) (Active) protein (GST tag,His tag)EPHA4 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 99 % as determined by reducing SDS-PAGE. Active
EPH Receptor A4 (EPHA4) (Active) protein (His tag)EPHA4 Origin: Rat Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
EPH Receptor A4 (EPHA4) (AA 20-547) protein (His tag)EPHA4 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS
EPH Receptor A4 (EPHA4) (Active) protein (Fc Tag)EPHA4 Origin: Rat Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- EPH Receptor A4 (EPHA4)
- Alternative Name
- EphA4 (EPHA4 Products)
- Background
- Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
- Molecular Weight
- 60.3 kDa
- NCBI Accession
- NP_004429
- Pathways
- RTK Signaling
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