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CCL19 Protein (AA 22-98)

CCL19 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 97 % by SDS PAGE CMA Active
Catalog No. ABIN6952156
  • Target See all CCL19 Proteins
    CCL19 (Chemokine (C-C Motif) Ligand 19 (CCL19))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 22-98
    Origin
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Source
    • 17
    • 3
    • 1
    Escherichia coli (E. coli)
    Application
    Cell Migration Assay (CMA)
    Sequence
    GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
    Characteristics
    Recombinant Human CCL19 (MIP-3beta)
    Purity
    > 97 % by SDS PAGE
    Endotoxin Level
    <0.01 EU per 1μg of the protein by the LAL method
    Biological Activity Comment
    EC50 = 7.0 nM determined by Migration Assay with recombinant human CCR7
    Top Product
    Discover our top product CCL19 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water
    Storage
    -20 °C,-80 °C
    Storage Comment
    12 months from date of receipt, -20 to -70 °C as supplied.
    Suggest to use immediately after reconstitution
    1 month at -20 to -70 °C under sterile conditions after reconstitution.
    Expiry Date
    12 months
  • Target
    CCL19 (Chemokine (C-C Motif) Ligand 19 (CCL19))
    Alternative Name
    CCL19 (MIP-3beta) (CCL19 Products)
    Synonyms
    CKb11 Protein, ELC Protein, MIP-3b Protein, MIP3B Protein, SCYA19 Protein, CCL19 Protein, Scya19 Protein, exodus-3 Protein, C-C motif chemokine ligand 19 Protein, chemokine (C-C motif) ligand 19 Protein, CCL19 Protein, ccl19 Protein, Ccl19 Protein
    Background
    Macrophage inflammatory protein-3-beta (MIP-3beta/CCL19), also known as EBI1 ligand chemokine (ELC), directs chemotaxis of dendritic cells, and certain B- and T- lymphocytes, but not monocytes or granulocytes. It is constituitively expressed in thymus and lymph nodes and binds specifically to target cells expressing the receptor CCR7. Being a homeostatic chemokine, its primary physiological role is considered to be in the normal recirculation and homing of lymphocyte. However, MIP-3beta could also be proinflammatory, and is implicated in the post-HIV infection responses.
    Molecular Weight
    8.800 kDa
    UniProt
    Q99731
    Pathways
    Positive Regulation of Immune Effector Process
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