CCL19 Protein (AA 22-98)
Quick Overview for CCL19 Protein (AA 22-98) (ABIN6952156)
Target
See all CCL19 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 22-98
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Sequence
- GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
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Characteristics
- Recombinant Human CCL19 (MIP-3beta)
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Endotoxin Level
- <0.01 EU per 1μg of the protein by the LAL method
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Biological Activity Comment
- EC50 = 7.0 nM determined by Migration Assay with recombinant human CCR7
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Chemokine (C-C Motif) Ligand 19 (CCL19) (AA 26-108) protein (His tag)
CCL19 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chemokine (C-C Motif) Ligand 19 (CCL19) (AA 22-98) protein (Fc Tag)CCL19 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Chemokine (C-C Motif) Ligand 19 (CCL19) (AA 1-98) protein (GST tag)CCL19 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Chemokine (C-C Motif) Ligand 19 (CCL19) (AA 22-98) protein (T7 tag)CCL19 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
Chemokine (C-C Motif) Ligand 19 (CCL19) (AA 22-98) (Active) protein (Biotin)CCL19 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 97 % by SDS PAGE CMA Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water
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Storage
- -20 °C,-80 °C
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Storage Comment
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12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution. -
Expiry Date
- 12 months
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- CCL19 (Chemokine (C-C Motif) Ligand 19 (CCL19))
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Alternative Name
- CCL19 (MIP-3beta)
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Background
- Macrophage inflammatory protein-3-beta (MIP-3beta/CCL19), also known as EBI1 ligand chemokine (ELC), directs chemotaxis of dendritic cells, and certain B- and T- lymphocytes, but not monocytes or granulocytes. It is constituitively expressed in thymus and lymph nodes and binds specifically to target cells expressing the receptor CCR7. Being a homeostatic chemokine, its primary physiological role is considered to be in the normal recirculation and homing of lymphocyte. However, MIP-3beta could also be proinflammatory, and is implicated in the post-HIV infection responses.
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Molecular Weight
- 8.800 kDa
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UniProt
- Q99731
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Pathways
- Positive Regulation of Immune Effector Process
Target
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