CCL4 Protein (AA 24-92) (Biotin)
Recombinant CCL4 protein expressed in Escherichia coli (E. coli).
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Catalog No. ABIN6952193
Quick Overview for CCL4 Protein (AA 24-92) (Biotin) (ABIN6952193)
Target
See all CCL4 Proteins
CCL4
(Chemokine (C-C Motif) Ligand 4 (CCL4))
Protein Type
Recombinant
Biological Activity
Active
Origin
Human
Source
Escherichia coli (E. coli)
Application
Cell Migration Assay (CMA)
Purity
> 97 % by SDS PAGE
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Protein Characteristics
- AA 24-92
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Purification tag / Conjugate
- This CCL4 protein is labelled with Biotin.
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Sequence
- APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN
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Characteristics
- Biotininylated Recombinant Human CCL4 (MIP-1beta)
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Endotoxin Level
- <0.01 EU per 1μg of the protein by the LAL method
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Biological Activity Comment
- EC50 = 0.32-1.3 nM determined by Migration Assay in cells expressing recombinant CCR5
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Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) (Active) protein
CCL4 Origin: Human Host: Escherichia coli (E. coli) Recombinant CMA Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water
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Storage
- -20 °C,-80 °C
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Storage Comment
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12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution. -
Expiry Date
- 12 months
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- CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))
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Alternative Name
- CCL4 (MIP-1beta)
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Background
- Monokine with inflammatory and chemokinetic properties binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta (3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
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Molecular Weight
- 10.238 kDa
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UniProt
- P13236
Target
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