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Fc epsilon RI/FCER1A Protein (AA 26-204) (Fc Tag)

FCER1A Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN6952258
  • Target See all Fc epsilon RI/FCER1A (FCER1A) Proteins
    Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 26-204
    Origin
    • 7
    • 5
    • 2
    • 1
    Human
    Source
    • 8
    • 3
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Fc epsilon RI/FCER1A protein is labelled with Fc Tag.
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product FCER1A Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Storage
    -20 °C
  • Target
    Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))
    Alternative Name
    Fc epsilon RI alpha (FCER1A Products)
    Synonyms
    FCER1A Protein, FCE1A Protein, FcERI Protein, Iger01 Protein, RATIGER01 Protein, Fce1a Protein, Fcr-5 Protein, fcepsilonri Protein, Fc fragment of IgE receptor Ia Protein, Fc receptor, IgE, high affinity I, alpha polypeptide Protein, FCER1A Protein, Fcer1a Protein
    Background
    High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.
    Molecular Weight
    47.3 kDa
    NCBI Accession
    NP_001992
    Pathways
    Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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