IL17C Protein (AA 19-197) (His tag)
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- Target See all IL17C Proteins
- IL17C (Interleukin 17C (IL17C))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 19-197
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL17C protein is labelled with His tag.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL17C Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- IL17C (Interleukin 17C (IL17C))
- Alternative Name
- IL-17C (IL17C Products)
- Synonyms
- IL17C Protein, il17-3 Protein, CX2 Protein, IL-17C Protein, IL-21 Protein, interleukin 17C Protein, interleukin 17c Protein, IL17C Protein, il17c Protein, Il17c Protein
- Background
- Interleukin-17C(IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.
- Molecular Weight
- 21.6 kDa
- NCBI Accession
- NP_037410
- Pathways
- Cellular Response to Molecule of Bacterial Origin
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