CD38 Protein (AA 43-300) (Fc-His Tag)
Quick Overview for CD38 Protein (AA 43-300) (Fc-His Tag) (ABIN6961077)
Target
See all CD38 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 43-300
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Purification tag / Conjugate
- This CD38 protein is labelled with Fc-His Tag.
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Purpose
- Recombinant human CD38 protein with C-terminal human Fc and 6xHis tag
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Specificity
- CD38 (Val43-Ile300) hFc (Glu99-Ala330) 6xHis tag
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- CD38
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Background
- CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2 . The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
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Molecular Weight
- predicted molecular mass of 70-72 kDa after removal of the signal peptide.
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Gene ID
- 952
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UniProt
- P28907
Target
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