ICOSLG Protein (AA 19-256) (His tag,mFc Tag)
Quick Overview for ICOSLG Protein (AA 19-256) (His tag,mFc Tag) (ABIN6961102)
Target
See all ICOSLG ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 19-256
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Purification tag / Conjugate
- This ICOSLG protein is labelled with His tag,mFc Tag.
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Purpose
- Recombinant human B7-H2 protein with C-terminal mouse Fc and 6xHis tag
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Specificity
- B7H2(Asp19-Thr256) mFc(Pro99-Lys330) 6xHis tag
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) (Active) protein (His-Avi Tag)
ICOSLG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) (Active) protein (hFc Tag)ICOSLG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) (Active) protein (Biotin,His-Avi Tag)ICOSLG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) (Active) protein (His tag)ICOSLG Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 47-279) (Active) protein (His tag)ICOSLG Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 18-256) protein (His-DYKDDDDK-Strep II Tag)ICOSLG Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 18-135) protein (His-DYKDDDDK-Strep II Tag)ICOSLG Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 20-302) protein (GST tag)ICOSLG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) (Active) protein (His tag)ICOSLG Origin: Human Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, ELISA, Imm, AcA Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 47-279) (Active) protein (His tag)ICOSLG Origin: Mouse Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, ELISA, Imm, AcA Active
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
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Alternative Name
- B7-H2
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Background
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ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2.The protein is the ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion, induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function -
Molecular Weight
- predicted molecular mass of 53.9 kDa after removal of the signal peptide.
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Gene ID
- 23308
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UniProt
- O75144
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Pathways
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
Target
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