FCGR3A Protein (AA 17-206) (His tag)
Quick Overview for FCGR3A Protein (AA 17-206) (His tag) (ABIN6961127)
Target
See all FCGR3A ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 17-206
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Purification tag / Conjugate
- This FCGR3A protein is labelled with His tag.
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Purpose
- Recombinant human FCGR3A protein(F176V) with C-terminal 6xHis tag
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Specificity
- FCGR3A (Gly17-Gly206) (F176V) 6xHis tag
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
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Alternative Name
- FCGR3A
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Background
- This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Molecular Weight
- predicted molecular mass of 22.3 kDa after removal of the signal peptide.
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Gene ID
- 2214
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UniProt
- P08637
Target
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