IL5RA Protein (AA 21-338) (His tag)
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- Target See all IL5RA Proteins
- IL5RA (Interleukin 5 Receptor, alpha (IL5RA))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 21-338
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL5RA protein is labelled with His tag.
- Purpose
- Recombinant human L5RA protein with C-terminal 6xHis tag
- Specificity
- IL5RA (Asp21-Pro338) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product IL5RA Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- IL5RA (Interleukin 5 Receptor, alpha (IL5RA))
- Alternative Name
- IL5RA (IL5RA Products)
- Background
- The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.
- Molecular Weight
- predicted molecular mass of 37.0 kDa after removal of the signal peptide.The apparent molecular mass of IL5RA-His is 50-55 kDa due to glycosylation.
- Gene ID
- 3568
- UniProt
- Q01344
- Pathways
- JAK-STAT Signaling
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