PD-1 Protein (AA 25-167) (Fc-His Tag)

Catalog No. ABIN6961149

This Recombinant PD-1 protein is produced in HEK-293 Cells.

Quick Overview for PD-1 Protein (AA 25-167) (Fc-His Tag) (ABIN6961149)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: ELISA

Purity: The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 25-167

Purification tag / Conjugate: This PD-1 protein is labelled with Fc-His Tag.

Purpose: Recombinant human PD-1 protein with C-terminal human Fc and 6xHis tag

Specificity: PD-1 (Leu25-Gln167) hFc (Glu99-Ala330) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: PD-1

Background: This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Molecular Weight: predicted molecular mass of 42.9 kDa after removal of the signal peptide.

Gene ID: 5133

UniProt: Q15116

Pathways: Cancer Immune Checkpoints