CNR1 Protein (AA 1-116) (Fc Tag)

Catalog No. ABIN6964092

This Recombinant CNR1 protein is produced in HEK-293 Cells.

Quick Overview for CNR1 Protein (AA 1-116) (Fc Tag) (ABIN6964092)

Target: CNR1 (Cannabinoid Receptor 1 (CNR1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 1-116

Purification tag / Conjugate: This CNR1 protein is labelled with Fc Tag.

Purpose: Recombinant Human CB1 protein with C-terminal human Fc

Specificity: CB1(Met1-Gln116) hFc(Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CNR1 (Cannabinoid Receptor 1 (CNR1))

Alternative Name: CB1

Background: CANN6,CB-R,CB1,CB1A,CB1K5,CB1R,CNR
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

Molecular Weight: predicted molecular mass of 39.3 kDa after removal of the signal peptide.The apparent molecular mass of CB1-hFc is 55-70 kDa due to glycosylation.

Gene ID: 1268

UniProt: P21554

Pathways: Feeding Behaviour