KLRG1 Protein (AA 99-330) (Fc Tag)

Catalog No. ABIN6964166

Recombinant KLRG1 protein expressed in HEK-293 Cells.

Quick Overview for KLRG1 Protein (AA 99-330) (Fc Tag) (ABIN6964166)

Target: KLRG1 (Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Purity: The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 99-330

Purification tag / Conjugate: This KLRG1 protein is labelled with Fc Tag.

Purpose: Recombinant Human KLRG1 protein with N-terminal human Fc

Specificity: HFc(Glu99-Ala330) KLRG1(Leu60-Phe195)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: KLRG1 (Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1))

Alternative Name: KLRG1

Background: CLEC15A,MAFA,MAFAL
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules.

Molecular Weight: predicted molecular mass of 41.6 kDa after removal of the signal peptide.The apparent molecular mass of hFc-KLRG1 is 55-70 kDa due to glycosylation.

Gene ID: 10219

UniProt: Q96E93