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ERG Protein (Fc Tag)

Recombinant ERG protein expressed in HEK-293 Cells.
Catalog No. ABIN6964259
$614.22
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Quick Overview for ERG Protein (Fc Tag) (ABIN6964259)

Target

See all ERG Proteins
ERG (ERG, ETS transcription factor (ERG))

Protein Type

Recombinant

Origin

  • 9
  • 3
  • 1
  • 1
Human

Source

  • 4
  • 3
  • 2
  • 2
  • 1
HEK-293 Cells
  • Purification tag / Conjugate

    This ERG protein is labelled with Fc Tag.

    Sequence

    ERG(Val280-Glu405)+hFc(Glu99-Ala330)

    Characteristics

    Tagged Protein: C-Human Fc tag

    Purification

    affinity purification
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  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Reconstitute with deionized water

    Buffer

    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

    Preservative

    Without preservative

    Storage

    -80 °C

    Storage Comment

    Store at -80°C for 12 months (Avoid repeated freezing and thawing)

    Expiry Date

    12 months
  • Target

    ERG (ERG, ETS transcription factor (ERG))

    Alternative Name

    ERG

    Background

    Synonymes: erg-3, p55
    Description: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

    Molecular Weight

    49.39 kDa

    UniProt

    P11308
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