ERG Protein (Fc Tag)
Quick Overview for ERG Protein (Fc Tag) (ABIN6964259)
Target
See all ERG ProteinsProtein Type
Origin
Source
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Purification tag / Conjugate
- This ERG protein is labelled with Fc Tag.
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Sequence
- ERG(Val280-Glu405)+hFc(Glu99-Ala330)
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Characteristics
- Tagged Protein: C-Human Fc tag
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Purification
- affinity purification
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with deionized water
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Preservative
- Without preservative
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Storage
- -80 °C
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Storage Comment
- Store at -80°C for 12 months (Avoid repeated freezing and thawing)
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Expiry Date
- 12 months
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- ERG (ERG, ETS transcription factor (ERG))
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Alternative Name
- ERG
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Background
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Synonymes: erg-3, p55
Description: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014] -
Molecular Weight
- 49.39 kDa
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UniProt
- P11308
Target
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