Multidrug-Resistance Like Protein 1 Protein (MRP) (Fc Tag)

Catalog No. ABIN6964296

This Recombinant Multidrug-Resistance Like Protein 1 protein is produced in HEK-293 Cells.

Quick Overview for Multidrug-Resistance Like Protein 1 Protein (MRP) (Fc Tag) (ABIN6964296)

Target: Multidrug-Resistance Like Protein 1 (MRP)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Product Details

Purification tag / Conjugate: This Multidrug-Resistance Like Protein 1 protein is labelled with Fc Tag.

Sequence: MRP1(Met1-Phe33)+hFc(Glu99-Ala330)

Characteristics: Tagged Protein: C-Human Fc tag

Purification: affinity purification

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Preservative: Without preservative

Storage: -80 °C

Storage Comment: Store at -80°C for 12 months (Avoid repeated freezing and thawing)

Expiry Date: 12 months

Target Details

Target: Multidrug-Resistance Like Protein 1 (MRP)

Alternative Name: MRP1

Background: Synonymes: HDMX, MDMX, MRP1
Description: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Molecular Weight: 29.15 kDa

UniProt: P33527