Neuregulin 1 Protein (NRG1) (AA 20-242) (Fc Tag)

Catalog No. ABIN6964402

This Recombinant Neuregulin 1 protein is expressed in HEK-293 Cells.

Quick Overview for Neuregulin 1 Protein (NRG1) (AA 20-242) (Fc Tag) (ABIN6964402)

Target: Neuregulin 1 (NRG1)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: ELISA

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 20-242

Purification tag / Conjugate: This Neuregulin 1 protein is labelled with Fc Tag.

Purpose: Recombinant human NRG1 Protein with C-terminal Human Fc tag

Specificity: NRG1 (Ser20-Arg242) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1

Background: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Molecular Weight: predicted molecular mass of 50.3 kDa after removal of the signal peptide.The apparent molecular mass of NRG1-hFc is 55-70 kDa due to glycosylation.

Gene ID: 3084

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation