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CD70 Protein (AA 52-193) (His tag,DYKDDDDK Tag,FITC)

CD70 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Catalog No. ABIN6972978
  • Target See all CD70 Proteins
    CD70 (CD70 Molecule (CD70))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 52-193
    Origin
    • 31
    • 9
    • 1
    • 1
    • 1
    Human
    Source
    • 26
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CD70 protein is labelled with His tag,DYKDDDDK Tag,FITC.
    Characteristics
    FITC-Labeled Human CD27 Ligand / CD70 Protein, His,Flag Tag active trimer (MALS verified)
    Purity
    >90 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD70 Protein
  • Application Notes
    MALS verified
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -20 °C
  • Target
    CD70 (CD70 Molecule (CD70))
    Alternative Name
    CD27 Ligand (CD70 Products)
    Background
    Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.
    Molecular Weight
    49.3 kDa
    Pathways
    Cancer Immune Checkpoints
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