Plexin B2 Protein (PLXNB2) (AA 20-1160) (His tag)

Catalog No. ABIN7013018

This Recombinant Plexin B2 protein is expressed in HEK-293 Cells.

Quick Overview for Plexin B2 Protein (PLXNB2) (AA 20-1160) (His tag) (ABIN7013018)

Target: Plexin B2 (PLXNB2)

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: >90 % as determined by reduced SDS-PAGE.

Product Details

Protein Characteristics: AA 20-1160

Purification tag / Conjugate: This Plexin B2 protein is labelled with His tag.

Purpose: Human Plexin B2 Protein, His Tag

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Target Details

Target: Plexin B2 (PLXNB2)

Alternative Name: Plexin B2

Background: Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.

Molecular Weight: 127.0 kDa

NCBI Accession: NP_036533

Pathways: Tube Formation