Integrin alpha 10 beta 1 (AA 23-1118) (Active) protein (His tag)

Catalog No. ABIN7013063

This Recombinant Integrin alpha 10 beta 1 protein is expressed in HEK-293 Cells.

Quick Overview for Integrin alpha 10 beta 1 (AA 23-1118) (Active) protein (His tag) (ABIN7013063)

Target: Integrin alpha 10 beta 1

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purity: >90 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 23-1118

Purification tag / Conjugate: His tag

Purpose: Mouse Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein, His Tag&Tag Free

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Storage: -20 °C

Target Details

Target: Integrin alpha 10 beta 1

Background: Human integrin alpha(10)I domain as a recombinant protein to reveal its ligand binding specificity. In general, alpha(10)I did recognize collagen types I-VI and laminin-1 in a Mg(2+)-dependent manner, whereas its binding to tenascin was only slightly better than to albumin. Alpha 10 beta 1 is a known collagen-binding I domain integrin, in addition to α1β1, α2β1 and α11β1. GROGER found in the N-terminal domain of collagens I and III, is only weakly recognised by α10β1, an important collagen receptor on chondrocytes, contrasting with the other collagen-binding integrins.

Molecular Weight: 126.6 kDa (ITGA10) & 83.5 kDa (ITGB1)