Syndecan 1 Protein (SDC1) (AA 23-254) (His tag)

Catalog No. ABIN7013604

Product Details

Target: Syndecan 1 (SDC1)

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 23-254

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Syndecan 1 protein is labelled with His tag.

Sequence: AA 23-254

Characteristics: Human Syndecan-1 Protein, Fc Tag

Purity: >90 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Target Details

Target: Syndecan 1 (SDC1)

Alternative Name: Syndecan-1 (SDC1 Products)

Background: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Molecular Weight: 25.8 kDa

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism