CCR6 Protein (AA 1-47) (Fc Tag)

Catalog No. ABIN7092813

Recombinant CCR6 protein expressed in HEK-293 Cells.

Quick Overview for CCR6 Protein (AA 1-47) (Fc Tag) (ABIN7092813)

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 1-47

Purification tag / Conjugate: This CCR6 protein is labelled with Fc Tag.

Purpose: Recombinant Human CCR6 with C-terminal human Fc tag

Specificity: CCR6(Met1-Leu47) hFc(Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Alternative Name: CCR6

Background: BN-1,C-C CKR-6,CC-CKR-6,CCR-6,CD196,CKR-L3,CKRL3,CMKBR6,DCR2,DRY6,GPR29,GPRCY4,STRL22
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Molecular Weight: predicted molecular mass of 31.6 kDa after removal of the signal peptide. The apparent molecular mass of CCR6-hFc is 35-55 kDa due to glycosylation.

UniProt: P51684

Pathways: cAMP Metabolic Process