CCR5 Protein-VLP
Quick Overview for CCR5 Protein-VLP (ABIN7199042)
Target
See all CCR5 ProteinsProtein Type
Origin
Source
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Purpose
- Human CCR5 Full Length Protein-VLP (HEK293)
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Sequence
- Met 1 - Leu 352
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Characteristics
- Human CCR5 Full Length Protein-VLP (CC5-H52P3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Leu 352 (Accession # P51681-1).
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-354) protein (His tag)
custom-made CCR5 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-352) protein (His tag)custom-made CCR5 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Chemokine (C-C Motif) Receptor 5 (CCR5) proteinCCR5 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-352) protein (GST tag)CCR5 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-30) protein (Fc Tag)CCR5 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 2-223), (AA 227-319) (Active) protein (His tag,DYKDDDDK Tag)CCR5 Origin: Human Host: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE. Active
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Application Notes
- The protein has a calculated MW of 40.5 kDa.
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Comment
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Virus-like particles (VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display. -
Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS, pH 7.4
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Storage
- -80 °C
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Storage Comment
- -70°C
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- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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Alternative Name
- CCR5
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Background
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Synonyms: CCR5,CMKBR5,CD195,CC-CKR-5,CHEMR13,
Description: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.5 Publications (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. -
Molecular Weight
- 40.5 kDa
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Pathways
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
Target
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