Aconitase 1 Protein (ACO1) (His tag)
Quick Overview for Aconitase 1 Protein (ACO1) (His tag) (ABIN7194099)
Target
See all Aconitase 1 (ACO1) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This Aconitase 1 protein is labelled with His tag.
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Purpose
- Recombinant Human ACO1/irp1 Protein (His Tag)
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Sequence
- Met 1-Lys 889
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Characteristics
- A DNA sequence encoding the human ACO1 (P21399) (Met 1-Lys 889) was expressed, with a polyhistidine tag at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Aconitase 1 (ACO1) (AA 1-889) protein (His tag)
custom-made ACO1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Aconitase 1 (ACO1) (AA 1-889) protein (His tag)custom-made ACO1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Aconitase 1 (ACO1) (AA 780-889) protein (GST tag)ACO1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Aconitase 1 (ACO1) (AA 1-889) protein (GST tag)ACO1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Aconitase 1 (ACO1) (AA 1-889) protein (His tag)ACO1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol, 2 mM DTT
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Aconitase 1 (ACO1)
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Alternative Name
- ACO1/irp1
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Background
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Background: Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and the other is mitochondrial. ACO1 is the soluble existing form, and the mitochondrial form is ACO2. Residues from all three N-terminal domains and the larger C-terminal domain contribute to the active site region. When the enzyme is activated, it gains an additional iron atom. ACO1 can assume two different functions in cells, depending on different conditions. During iron scarcity or oxidative stress, ACO1 binds to mRNA stem-loop structures called iron responsive elements to modulate the translation of iron metabolism genes. In iron-rich conditions, ACO1 binds an iron-sulfur cluster to function as a cytosolic aconitase.
Synonym: ACONS;HEL60;IREB1;IREBP;IREBP1;IRP1
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Molecular Weight
- 101 kDa
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UniProt
- P21399
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Pathways
- Transition Metal Ion Homeostasis
Target
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