Arylsulfatase A Protein (ARSA) (His tag)

Catalog No. ABIN7318179

Recombinant Arylsulfatase A protein expressed in Human Cells.

Quick Overview for Arylsulfatase A Protein (ARSA) (His tag) (ABIN7318179)

Target: Arylsulfatase A (ARSA)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Arylsulfatase A protein is labelled with His tag.

Purpose: Recombinant Human Arylsulfatase A/ARSA Protein (His Tag)

Sequence: Arg19-Ala507

Characteristics: Recombinant Human Arylsulfatase A is produced by our Mammalian expression system and the target gene encoding Arg19-Ala507 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 7.5.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: Arylsulfatase A (ARSA)

Alternative Name: Arylsulfatase A/ARSA

Background:

Background: Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down Cerebroside 3-Sulfate, a major constituent of the myelin sheet, into Cerebroside and Sulfate. The ARSA deficiency results in Metachromatic Leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. Recombinant Human ARSA corresponds to the ARSA mature peptide and has sulfatase activity.

Synonym: Arylsulfatase A, ASA, Cerebroside-Sulfatase, ARSA

Molecular Weight: 52.9 kDa

UniProt: P15289