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BCL2L2 Protein (His tag)

This Recombinant BCL2L2 protein is produced in Escherichia coli (E. coli).
Catalog No. ABIN7318198
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Quick Overview for BCL2L2 Protein (His tag) (ABIN7318198)

Target

See all BCL2L2 Proteins
BCL2L2 (BCL2-Like 2 (BCL2L2))

Protein Type

Recombinant

Origin

  • 10
  • 3
  • 2
  • 1
  • 1
Human

Source

  • 12
  • 2
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Purity

> 95 % as determined by reducing SDS-PAGE.
  • Purification tag / Conjugate

    This BCL2L2 protein is labelled with His tag.

    Purpose

    Recombinant Human BCL-W/BCL2L2 Protein (His Tag)

    Sequence

    Ala2-Thr172

    Characteristics

    Recombinant Human B Cell Lymphoma/Leukemia w is produced by our E.coli expression system and the target gene encoding Ala2-Thr172 is expressed with a 6His tag at the C-terminus.

    Endotoxin Level

    < 1.0 EU per μg as determined by the LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Frozen, Liquid

    Buffer

    Supplied as a 0.2 μm filtered solution of 25 mM HEPES, 100 mM KCl, 20 % Glycerol, pH 7.5.

    Storage

    -20 °C

    Storage Comment

    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target

    BCL2L2 (BCL2-Like 2 (BCL2L2))

    Alternative Name

    BCL-W/BCL2L2

    Background

    Background: Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

    Synonym: Bcl-2-Like Protein 2, Bcl2-L-2, Apoptosis Regulator Bcl-W, BCL2L2, BCLW, KIAA0271

    Molecular Weight

    19.9 kDa

    UniProt

    Q92843
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