BNIP3L/NIX Protein
Quick Overview for BNIP3L/NIX Protein (ABIN7317369)
Target
See all BNIP3L/NIX (BNIP3L) ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human BNIP3L Protein
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Sequence
- Ser 2-Lys 187
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Characteristics
- A DNA sequence encoding the human BNIP3L (NP_004322.1) (Ser 2-Lys 187) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
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BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (AA 1-218) protein (His tag)
custom-made BNIP3L Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (AA 1-219) protein (His tag)custom-made BNIP3L Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (AA 3-103) protein (His-IF2DI Tag)BNIP3L Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (AA 1-219), (full length) protein (His tag)BNIP3L Origin: Human Host: Yeast Recombinant > 90 % SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 50 mM Tris, 150 mM NaCl, 1 mM DTT, pH 8.0
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))
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Alternative Name
- BNIP3L
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Background
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Background: The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to rid the cells of the last remaining 'living' characteristic, thus completing the march from 'living' to 'dead' within the hair follicle. during retinal development tissue hypoxia triggers HIF1A/HIF-1 stabilization, resulting in increased expression of the mitophagy receptor BNIP3L/NIX. BNIP3L-dependent mitophagy results in a metabolic shift toward glycolysis essential for RGC neurogenesis. BNIP3L could be a potential therapeutic target for ischemic stroke
Synonym: BNIP3a,NIX
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Molecular Weight
- 20.4 kDa
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Pathways
- Autophagy
Target
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