Calreticulin 3 Protein (CALR3)
Quick Overview for Calreticulin 3 Protein (CALR3) (ABIN7318227)
Target
See all Calreticulin 3 (CALR3) ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human Calreticulin-3/CALR3 Protein
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Sequence
- Thr 20-Leu384
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Characteristics
- Recombinant Human calreticulin-3 is produced by our E.coli expression system and the target gene encoding Thr20-Leu384 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Calreticulin 3 (CALR3) (AA 20-384) protein (His tag)
CALR3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Calreticulin 3 (CALR3) (AA 21-384) protein (GST tag)CALR3 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Calreticulin 3 (CALR3) protein (Myc-DYKDDDDK Tag)CALR3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Calreticulin 3 (CALR3)
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Alternative Name
- Calreticulin-3/CALR3
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Background
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Background: Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain.
Synonym: Calreticulin-3, calreticulin-2, calsperin, CALR3, CRT2
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Molecular Weight
- 42.9 kDa
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UniProt
- Q96L12
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Pathways
- Activation of Innate immune Response
Target
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