Cathepsin S Protein (CTSS) (His tag)

Catalog No. ABIN7320704

This Recombinant Cathepsin S protein is expressed in Human Cells.

Quick Overview for Cathepsin S Protein (CTSS) (His tag) (ABIN7320704)

Target: Cathepsin S (CTSS)

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Cathepsin S protein is labelled with His tag.

Purpose: Recombinant Mouse Cathepsin S/CTSS Protein (His Tag)

Sequence: Val18-Ile340

Characteristics: Recombinant Mouse Cathepsin S is produced by our Mammalian expression system and the target gene encoding Val18-Ile340 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Cathepsin S (CTSS)

Alternative Name: Cathepsin S/CTSS

Background:

Background: Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer's disease (AD) and Down Syndrome (DS).

Synonym: Cathepsin S, CTSS

Molecular Weight: 37.5 kDa

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades