DC-SIGN/CD209 Protein (Fc Tag)
Quick Overview for DC-SIGN/CD209 Protein (Fc Tag) (ABIN7319880)
Target
See all DC-SIGN/CD209 (CD209) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This DC-SIGN/CD209 protein is labelled with Fc Tag.
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Purpose
- Recombinant Human DC-SIGN/CD209 (N-Fc)
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Sequence
- Gln59-Ala404
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Characteristics
- Recombinant Human CD209 Antigen is produced by our Mammalian expression system and the target gene encoding Gln59-Ala404 is expressed with a Fc tag at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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CD209 (CD209) (AA 59-404) protein (His tag)
CD209 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD209 (CD209) (AA 1-404) protein (His tag)custom-made CD209 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
CD209 (CD209) (AA 271-380) protein (GST tag)CD209 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
CD209 (CD209) (AA 1-404) protein (GST tag)CD209 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- DC-SIGN/CD209 (CD209) (CD209)
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Alternative Name
- DC-SIGN/CD209
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Background
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Background: CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. The DC-SIGN/CD209 lectin domain binds mannose oligosaccharides on pathogens including HIV as well as self glycoproteins including ICAMs (2, 4). DC-SIGN/CD209 binds to butyrophilin 2A1 and this interaction can be blocked by HIV pp120. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors.
Synonym: CD209 Molecule, CD209, CDSIGNHIV gpl20-binding protein, CLEC4L, DCSIGN, DC-SIGN, DC-SIGN1, CD209 Antigen
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Molecular Weight
- 65.3 kDa
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UniProt
- Q9NNX6
Target
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