CD300a Protein (CD300A) (Fc Tag)

Catalog No. ABIN7320607

Recombinant CD300a protein expressed in Human Cells.

Quick Overview for CD300a Protein (CD300A) (Fc Tag) (ABIN7320607)

Target: CD300a (CD300A)

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This CD300a protein is labelled with Fc Tag.

Purpose: Recombinant Mouse CD300a/LMIR1 Protein (Fc Tag)

Sequence: Leu28-Arg183

Characteristics: Recombinant Mouse Leukocyte mono-Ig-like receptor 1 is produced by our Mammalian expression system and the target gene encoding Leu28-Arg183 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD300a (CD300A)

Alternative Name: CD300a/LMIR1

Background:

Background: LMIR1, also termed CD300a, is a type I transmembrane glycoprotein with a single IgV-like extracellular domain and an extended membrane proximal region that links the immunoglobulin (Ig) and transmembrane domains and belongs to the immunoglobulin superfamily. The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs). When cross-linked, it will be tyrosine phosphorylated and capable of recruiting tyrosine phosphatases (SHP-1, SHP-2) and inositol polyphosphate 5-phosphatase, SHIP. LMIR1 will regulate mast cell-mediated inflammatory responses. LMIR1 is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type.

Synonym: CD300a,CD300a antigen,CMRF35H9, CD300a molecule, leukocyte immunoglobulin-like receptor,CD300 antigen-like family member A, CMRF35-like molecule 8,NK inhibitory receptor, Immunoglobulin superfamily member 12, IRp60,Inhibitory receptor protein 60, CLM8, CMRF-35H, IGSF12, IRC1, IRC2, LMIR1,CLM-8,MAIR-I,Clm8,MAIR-I,MAIR-Ia,mcpir1,MMAC8,Pigr4

Molecular Weight: 44.3 kDa

UniProt: Q6SJQ0

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process