Quick Overview for CD59 Protein (CD59) (His tag) (ABIN7319910)
Target
See all CD59 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This CD59 protein is labelled with His tag.
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Purpose
- Recombinant Human CD59 (C-6His)
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Sequence
- Leu26-Asn102
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Characteristics
- Recombinant Human CD59 Glycoprotein is produced by our Mammalian expression system and the target gene encoding Leu26-Asn102 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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CD59 (CD59) (AA 26-102) protein (Fc Tag)
CD59 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD59 (CD59) (AA 1-128) protein (GST tag)CD59 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CD59
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Alternative Name
- CD59
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Background
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Background: CD59, also known as membrane attack complex inhibition factor (MACIF), Protectin, 1F5 antigen, HRF-20 and MIRL, is an approximately 20 kDa GPI anchored glycoprotein that is an important regulator of the complement system in blood. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Synonym: 1F5 antigen, 1F5, 20 kDa homologous restriction factor, CD59 antigen, CD59 glycoprotein, CD59, HRF20, HRF-20, MACIF, MAC-IP, MIC11, MIC11MSK21, MIN1, MIN2, MIN3, MIRL, p18-20, 16.3A5, EL32, FLJ38134, FLJ92039, G344
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Molecular Weight
- 9.8 kDa
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UniProt
- P13987
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Pathways
- Complement System
Target
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