CD59a Protein (CD59A) (Fc Tag)
Quick Overview for CD59a Protein (CD59A) (Fc Tag) (ABIN7320174)
Target
See all CD59a (CD59A) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This CD59a protein is labelled with Fc Tag.
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Purpose
- Recombinant Mouse CD59a/MAC-IP Protein (Fc Tag)
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Sequence
- Met 1-Lys 95
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Characteristics
- A DNA sequence encoding the mouse CD59a (O55186) (Met 1-Lys 95),without the pro peptide, was fused with the Fc region of human IgG1 at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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CD59a (CD59A) (AA 24-96) protein (Fc Tag)
CD59A Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD59a (CD59A) protein (His tag)CD59A Origin: Mouse Host: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CD59a (CD59A)
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Alternative Name
- CD59a/MAC-IP
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Background
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Background: Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins.It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor, it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.
Synonym: AA987121,Cd59,protectin,RP24-297H17.1
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Molecular Weight
- 35.4 kDa
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UniProt
- O55186
Target
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