CD80 Protein (CD80) (Fc Tag)

Catalog No. ABIN7320950

This Recombinant CD80 protein is expressed in Human Cells.

Quick Overview for CD80 Protein (CD80) (Fc Tag) (ABIN7320950)

Target: CD80

Protein Type: Recombinant

Origin: Cynomolgus

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This CD80 protein is labelled with Fc Tag.

Purpose: Recombinant Cynomolgus B7-1/CD80 Protein (Fc Tag)

Sequence: Val35-Asn242

Characteristics: Recombinant Cynomolgus CD80 is produced by our Mammalian expression system and the target gene encoding Val35-Asn242 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD80

Alternative Name: B7-1/CD80

Background:

Background: Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Synonym: T-lymphocyte activation antigen CD80, Activation B7-1 antigen, B7, CD80

Molecular Weight: 51 kDa

UniProt: G7NXN7

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints