CD86 Protein (CD86) (Fc Tag)

Catalog No. ABIN7320949

This Recombinant CD86 protein is expressed in Human Cells.

Quick Overview for CD86 Protein (CD86) (Fc Tag) (ABIN7320949)

Target: CD86

Protein Type: Recombinant

Origin: Cynomolgus

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This CD86 protein is labelled with Fc Tag.

Purpose: Recombinant Cynomolgus B7-2/CD86 Protein (Fc Tag)

Sequence: Ala19-His240

Characteristics: Recombinant Cynomolgus CD86 is produced by our Mammalian expression system and the target gene encoding Ala19-His240 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD86

Alternative Name: B7-2/CD86

Background:

Background: T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.

Synonym: T-lymphocyte activation antigen CD86 isoform 1,Activation B7-2 antigen, CD86

Molecular Weight: 52.5 kDa

UniProt: G7NXR4

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation