CD8B Protein (His tag)

Catalog No. ABIN7319333

Recombinant CD8B protein expressed in Human Cells.

Quick Overview for CD8B Protein (His tag) (ABIN7319333)

Target: CD8B (CD8b Molecule (CD8B))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 90 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This CD8B protein is labelled with His tag.

Purpose: Recombinant Human CD8 beta/CD8B Protein (His Tag)

Sequence: Leu22-Pro170

Characteristics: Recombinant Human T-Cell Surface Glycoprotein CD8 beta Chain is produced by our Mammalian expression system and the target gene encoding Leu22-Pro170 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD8B (CD8b Molecule (CD8B))

Alternative Name: CD8 beta/CD8B

Background:

Background: T-Cell Surface Glycoprotein CD8β Chain (CD8 Antigen) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 Antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

Synonym: T-Cell Surface Glycoprotein CD8 Beta Chain, CD8b, CD8B, CD8B1, LEU2, LY3, LYT3, P37

Molecular Weight: 17.8 kDa

Pathways: TCR Signaling