CXCL2 Protein

Catalog No. ABIN7320503

Recombinant CXCL2 protein expressed in Escherichia coli (E. coli).

Quick Overview for CXCL2 Protein (ABIN7320503)

Target: CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purpose: Recombinant Mouse CXCL2/MIP-2 Protein

Sequence: Ala28-Asn100

Characteristics: Recombinant Mouse C-X-C motif chemokine 2 is produced by our E.coli expression system and the target gene encoding Ala28-Asn100 is expressed.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))

Alternative Name: CXCL2/MIP-2

Background:

Background: C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63 % aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.

Synonym: MIP-2, chemokine ligand 2, C-X-C motif chemokine 2, GRO beta, GRO2, GROB, Gro-beta, Growth-regulated protein beta, Macrophage Inflammatory Protein-2-alpha, melanoma growth stimulatory activity beta, cxcl2, MGSA-b, MGSA-beta, MIP2A, MIP2-alpha, SCYB2.

Molecular Weight: 7.9 kDa

UniProt: P10889

Pathways: Cellular Response to Molecule of Bacterial Origin