CLDN18.2 protein (His tag)

Catalog No. ABIN7319933

Recombinant protein expressed in Escherichia coli (E. coli).

Quick Overview for CLDN18.2 protein (His tag) (ABIN7319933)

Target: CLDN18.2

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: His tag

Purpose: Recombinant Human CLDN18.2(N-6His,C-Avi)

Characteristics: Biotinylated Recombinant Human CLDN18.2 is produced by our E.coli expression system and the targetgene encoding extracellular is expressed with a 6His tag at the N-terminus.

Endotoxin Level: < 1.0 EU per g as determined by the LAL method.

Biological Activity Comment: Test in progress

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 8M Urea,150 mM NaCl, 5 mM β-ME, pH 8.5.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: CLDN18.2

Background:

Background: Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2.IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is underinvestigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

Synonym: Claudin-18.2, CLDN18

Molecular Weight: 12.6 kDa