Clusterin Protein (CLU) (His tag)

Catalog No. ABIN7320262

This Recombinant Clusterin protein is produced in HEK-293 Cells.

Quick Overview for Clusterin Protein (CLU) (His tag) (ABIN7320262)

Target: Clusterin (CLU)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 96 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Clusterin protein is labelled with His tag.

Purpose: Recombinant Mouse Clusterin/ApoJ Protein (His Tag)

Sequence: Met 1-Glu 448

Characteristics: A DNA sequence encoding the mouse CLU (NP_038520.2) (Met 1-Glu 448) was expressed, with a C-terminal polyhistidine tag.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Clusterin (CLU)

Alternative Name: Clusterin/ApoJ

Background:

Background: Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Synonym: Clusterin,Apolipoprotein J,Clustrin,Sulfated glycoprotein 2,ApoJ, Cli, D14Ucla3, Sgp-2, Sgp2, SP-40,Sugp-2

Molecular Weight: 50.8 kDa

NCBI Accession: NP_038520

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling