COLEC12 Protein (His tag)

Catalog No. ABIN7195183

This Recombinant COLEC12 protein is expressed in Baculovirus infected Insect Cells.

Quick Overview for COLEC12 Protein (His tag) (ABIN7195183)

Target: COLEC12 (Collectin Sub-Family Member 12 (COLEC12))

Protein Type: Recombinant

Origin: Rat

Source: Baculovirus infected Insect Cells

Purity: > 99 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This COLEC12 protein is labelled with His tag.

Purpose: Recombinant Rat CLP1/COLEC12 Protein (His Tag)

Sequence: Ala101-Leu742

Characteristics: A DNA sequence encoding the mature form of rat COLEC12 (Q4V885) (Ala101-Leu742) was expressed,with a polyhistide tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: COLEC12 (Collectin Sub-Family Member 12 (COLEC12))

Alternative Name: CLP1/COLEC12

Background:

Background: CLP1, also known as COLEC12, is a scavenger receptor that displays several functions associated with host defense. It contains 1 C-type lectin domain and 3 collagen-like domains. CLP1 is strongly expressed in placenta and moderately expressed in heart, skeletal muscle, small intestine and lung. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. CLP1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. It binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. It binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). CLP1 may also play a role in the clearance of amyloid beta in Alzheimer disease.

Synonym: Clp1,Nsr2,COLEC12

Molecular Weight: 72.4 kDa

UniProt: Q4V885

Pathways: Activation of Innate immune Response