Quick Overview for C3 Protein (ABIN7320494)
Target
See all C3 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Mouse Complement Component C3a/C3a Protein
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Sequence
- Ser671-Arg748
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Characteristics
- Recombinant Mouse Complement Component C3a is produced by our E.coli expression system and the target gene encoding Ser671-Arg748 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Complement Component 3 (C3) (AA 25-1663) protein (His tag)
C3 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Complement Component 3 (C3) (AA 23-1663) protein (His tag)C3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Complement Component 3 (C3) (AA 1534-1644) protein (GST tag)C3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- C3 (Complement Component 3 (C3))
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Alternative Name
- Complement Component C3a/C3a
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Background
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Background: Complement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent point for all three major complement activation pathways: namely classical, alternative and mannose-binding lectin pathways. Complement activation leads to the formation of the C3 convertase, which cleaves C3 into the key effector molecules, C3a (anaphylatoxin) and C3b (opsonin) which then drive microbe removal. By binding to C3a receptor (C3aR), C3a exhibits potent anaphylatoxin activity, including increased vascular permeability, triggering degranulation of mast cells, inflammation, and activating leukocytes.
Synonym: Complement Component C3a, Anaphylatoxin, C3a
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Molecular Weight
- 9.2 kDa
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UniProt
- P01027
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Pathways
- Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
Target
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