CKMT1A Protein (His tag)

Catalog No. ABIN7195282

This Recombinant CKMT1A protein is expressed in Baculovirus infected Insect Cells.

Quick Overview for CKMT1A Protein (His tag) (ABIN7195282)

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This CKMT1A protein is labelled with His tag.

Purpose: Recombinant Human CKMT1A Protein (His Tag)

Sequence: Ala 40-His 417

Characteristics: A DNA sequence encoding human CKMT1A (P12532-1) (Ala40-His417) was expressed, with a polyhistide tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.5, 10 % glycerol

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Alternative Name: CKMT1A

Background:

Background: CKMT1A belongs to the ATP:guanido phosphotransferase family. It contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. CKMT1A gene is one of two genes which encode the ubiquitous mitochondrial creatine kinase (CKMT1). CKMT1 is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK (CKMT2) and ubiquitous MtCK, encoded by separate genes. CKMT1 occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric CKMT1.

Synonym: CKMT,CKMT1,CKMT1A

Molecular Weight: 45.3 kDa