DCLK1 Protein
Quick Overview for DCLK1 Protein (ABIN7317531)
Target
See all DCLK1 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human DCAMKL1 Protein
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Sequence
- Met 1-Val 705
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Characteristics
- A DNA sequence encoding the human DCLK1 (O15075-1) (Met 1-Val 705) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Doublecortin-Like Kinase 1 (DCLK1) (AA 1-756) protein (His tag)
custom-made DCLK1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Doublecortin-Like Kinase 1 (DCLK1) (AA 1-740) protein (His tag)custom-made DCLK1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Doublecortin-Like Kinase 1 (DCLK1) (AA 586-740) protein (His-IF2DI Tag)DCLK1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Doublecortin-Like Kinase 1 (DCLK1) (AA 640-729) protein (GST tag)DCLK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Doublecortin-Like Kinase 1 (DCLK1) (AA 1-705) (Active) protein (GST tag,His tag)DCLK1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 84 % as determined by reducing SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
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Alternative Name
- DCAMKL1
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Background
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Background: DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.
Synonym: CL1,CLICK1,DCAMKL1,DCDC3A,DCLK
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Molecular Weight
- 78.5 kDa
Target
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