Ephrin A1 Protein (EFNA1) (His tag,Fc Tag)

Catalog No. ABIN7320512

This Recombinant Ephrin A1 protein is expressed in Human Cells.

Quick Overview for Ephrin A1 Protein (EFNA1) (His tag,Fc Tag) (ABIN7320512)

Target: Ephrin A1 (EFNA1)

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: Human Cells

Purity: > 90 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Ephrin A1 protein is labelled with His tag,Fc Tag.

Purpose: Recombinant Mouse Ephrin-A1/EFNA1 Protein (Fc & His Tag)(Active)

Sequence: Asp19-Ser182

Characteristics: Recombinant Mouse Ephrin-A1 is produced by our Mammalian expression system and the target gene encoding Asp19-Ser182 is expressed with a Fc, 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human EphA2-His(Cat: PKSH032009) at 0.5μg/ml(100 μl/well) can bind Human EFNA1-Fc. The ED50 of Human EFNA1-Fc is 12ug/ml.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Ephrin A1 (EFNA1)

Alternative Name: Ephrin-A1/EFNA1

Background:

Background: Ephrin-A1 is a cell membrane protein and contains 1 ephrin RBD (ephrin receptor-binding) domain. EFNA1 belongs to the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.It belongs to the ephrin family and contains 1 ephrin RBD (ephrin receptor-binding) domain.

Synonym: EPH-related receptor tyrosine kinase ligand 1, Immediate early response protein B61,Epgl1, Epl1, Lerk1

Molecular Weight: 47.3 kDa

UniProt: P52793

Pathways: RTK Signaling