EpCAM Protein (Fc Tag)

Catalog No. ABIN7320835

Product Details

Target: EpCAM (EPCAM) (Epithelial Cell Adhesion Molecule (EPCAM))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This EpCAM protein is labelled with Fc Tag.

Purpose: Recombinant Mouse EpCAM/TROP-1 Protein (Fc Tag)(Active)

Sequence: Gln24-Thr266

Characteristics: Recombinant Mouse EpCAM is produced by our Mammalian expression system and the target gene encoding Gln24-Thr266 is expressed with a Fc tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human CTSL2-His(Cat: PKSH032183) at 10μg/ml(100 μl/well) can bind Mouse EpCAM-Fc.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: EpCAM (EPCAM) (Epithelial Cell Adhesion Molecule (EPCAM))

Alternative Name: EpCAM/TROP-1 (EPCAM Products)

Background:

Background: ROR1,also known as Neurotrophic tyrosine kinase, receptor-related 1, belongs to the ROR subfamily of Tyr protein kinase family,a protein kinase superfamily. It has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. Human ROR1 shares 97 % and 58 % aa sequence identity with mouse ROR1 and human ROR2, respectively. ROR1 may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. Its Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Synonym: Neurotrophic tyrosine kinase receptor-related 1, receptor tyrosine kinase-like orphan receptor 1, ROR1,tyrosine-protein kinase transmembrane receptor ROR1, Epithelial cell adhesion molecule, Tumor-associated calcium signal transducer 1,TROP1,CD326,EGP,EGP-2,Egp314,Ep-CAM,EpCAM1,GA733-2,gp40,Ly74,Tacsd1,Tacstd1

Molecular Weight: 54.8 kDa

UniProt: Q99JW5