FZD5 Protein (Fc Tag)

Catalog No. ABIN7195862

Recombinant FZD5 protein expressed in CHO Cells.

Quick Overview for FZD5 Protein (Fc Tag) (ABIN7195862)

Target: FZD5 (Frizzled Family Receptor 5 (FZD5))

Protein Type: Recombinant

Origin: Mouse

Source: CHO Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This FZD5 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse Frizzled-5/FZD5 Protein (Fc Tag)

Sequence: Met1-Pro167

Characteristics: A DNA sequence encoding the mouse FZD5 (Q9EQD0) (Met1-Pro167) was expressed with the Fc region of human IgG1 at the C-terminus.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FZD5 (Frizzled Family Receptor 5 (FZD5))

Alternative Name: Frizzled-5/FZD5

Background:

Background: Wnt signaling is involved in a variety of embryonic development processes of nonvertebrates and vertebrates, where it determines cell motility, cell polarity, differentiation, proliferation and apoptosis, as well as formation of neural synapses. Various homologs of the Wingless protein, termed WNT factors, represent key mediators and act through a receptor complex comprised of members of the Frizzled and low density lipoprotein-related receptors (LRP). 19 WNTs, 10 Frizzled, and 2 LRP proteins have been identified. Frizzled is a family of G protein-coupled receptor proteins consisting of a divergent signal peptide, a highly conserved extracellular cysteine-rich domain (CRD), a variable-length linker region, a seven-pass transmembrane domain, and a variable-length C-terminal tail.Frizzled 5 (FZD5) is believed to be the receptor for the Wnt5A ligand, and also interactions with Wnt10B, Wnt2B, and Wnt 7A functionally. Recent studies of WNT5A/Frizzled-5 signaling have revealed an unexpected and novel role in orchestrating adaptive immunity in response to microbial stimulation. In addition, FZD5 is also implicated in the survival of mature neurons in the parafascicular nucleus of the thalamus.

Synonym: 5330434N09Rik,AI427138,Fz-5,Fz5,mFz5

Molecular Weight: 42.9 kDa

UniProt: Q9EQD0

Pathways: WNT Signaling