GABA Protein (GST tag)

Catalog No. ABIN7318511

This Recombinant GABA protein is expressed in Escherichia coli (E. coli).

Quick Overview for GABA Protein (GST tag) (ABIN7318511)

Target: GABA (gamma-Aminobutyric Acid (GABA))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This GABA protein is labelled with GST tag.

Purpose: Recombinant Human GABA Protein (GST Tag)

Sequence: Met 1-Lys117

Characteristics: Recombinant Human GABA(A) Receptor-Associated Protein is produced by our E.coli expression system and the target gene encoding Met1-Lys117 is expressed with a GST tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM TrisHCl, 200 mM NaCl, pH 7.5.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: GABA (gamma-Aminobutyric Acid (GABA))

Alternative Name: GABA

Target Type: Amino Acid

Background:

Background: Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.

Synonym: GABA(A) Receptor-Associated Protein, GABARAP Protein, HCG1987397 Isoform CRA_b, GABARAP

Molecular Weight: 40.2 kDa

UniProt: Q6IAW1