GNS Protein (His tag)
Quick Overview for GNS Protein (His tag) (ABIN7318800)
Target
See all GNS ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This GNS protein is labelled with His tag.
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Purpose
- Recombinant Human GNS Protein (His Tag)
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Sequence
- Val37-Leu552
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Characteristics
- Recombinant Human N-Acetylglucosamine-6-Sulfatase is produced by our Mammalian expression system and the target gene encoding Val37-Leu552 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Glucosamine (N-Acetyl)-6-Sulfatase (GNS) (AA 1-552) protein (GST tag)
GNS Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Glucosamine (N-Acetyl)-6-Sulfatase (GNS) protein (Myc-DYKDDDDK Tag)GNS Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl,10 % Glycerol, pH 8.0.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))
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Alternative Name
- GNS
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Background
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Background: N-Acetylglucosamine-6-Sulfatase is a member of the Sulfatase family. N-Acetylglucosamine-6-Sulfatase is required for the lysosomal degradation of the Glycosaminoglycans (GAG) Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase hydrolyzes the 6-Sulfate groups of the N-Acetyl-D-Glucosamine 6-Sulfate units of Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase binds 1 Calcium ion per subunit. N-Acetylglucosamine-6-Sulfatase deficiency are the cause of Mucopolysaccharidosis Type 3D (MPS3D), an inborn error leading to lysosomal accumulation of heparan sulfate. MPS3D has profound mental deterioration, hyperactivity, and relatively mild somatic manifestations.
Synonym: N-Acetylglucosamine-6-Sulfatase, Glucosamine-6-Sulfatase, G6S, GNS
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Molecular Weight
- 59.4 kDa
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UniProt
- P15586
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Pathways
- Glycosaminoglycan Metabolic Process
Target
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