GSTP1 Protein

Catalog No. ABIN7318541

This Recombinant GSTP1 protein is expressed in Escherichia coli (E. coli).

Quick Overview for GSTP1 Protein (ABIN7318541)

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Human GSTP1 Protein

Sequence: Met 1-Glu210

Characteristics: Recombinant Human Glutathione S-Transferase pi 1 is produced by our E.coli expression system and the target gene encoding Met1-Glu210 is expressed.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl,10 % Glycerol, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Alternative Name: GSTP1

Background:

Background: Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins. Besides, it regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. It thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Synonym: Glutathione S-transferase P,GSTP1,GST class-pi,GSTP1-1,FAEES3,GST3,

Molecular Weight: 23.5 kDa

UniProt: P09211

Pathways: Cellular Response to Molecule of Bacterial Origin