HMBS Protein (His tag)
Quick Overview for HMBS Protein (His tag) (ABIN7318923)
Target
See all HMBS ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This HMBS protein is labelled with His tag.
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Purpose
- Recombinant Human HMBS Protein (His Tag)
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Sequence
- Ser2-His361
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Characteristics
- Recombinant Human Porphobilinogen Deaminase is produced by our Mammalian expression system and the target gene encoding Ser2-His361 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Hydroxymethylbilane Synthase (HMBS) (AA 1-361) protein (His tag)
HMBS Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Hydroxymethylbilane Synthase (HMBS) (AA 1-361) protein (GST tag)HMBS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Hydroxymethylbilane Synthase (HMBS) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)HMBS Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Hydroxymethylbilane Synthase (HMBS) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)HMBS Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- HMBS (Hydroxymethylbilane Synthase (HMBS))
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Alternative Name
- HMBS
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Background
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Background: Porphobilinogen Deaminase (HMBS) is a member of the HMBS family. PBGD is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. HMBS is involved in the production of heme, which is important for all of the body's organs, although it is most abundant in the blood, bone marrow, and liver. In addition, Heme is an essential component of iron-containing proteins called hemoproteins, including hemoglobin. Defects in PBGD are the cause of acute intermittent porphyria.
Synonym: Porphobilinogen Deaminase, PBG-D, Hydroxymethylbilane Synthase, HMBS, Pre-Uroporphyrinogen Synthase, HMBS, PBGD, UPS
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Molecular Weight
- 40.5 kDa
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UniProt
- P08397
Target
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